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Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk

β-Lactoglobulin (BLG) is a major goat’s milk allergen that is absent in human milk. Engineered endonucleases, including transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases, enable targeted genetic modification in livestock. In this study, TALEN-mediated gene knockout f...

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Detalles Bibliográficos
Autores principales:	Cui, Chenchen, Song, Yujie, Liu, Jun, Ge, Hengtao, Li, Qian, Huang, Hui, Hu, Linyong, Zhu, Hongmei, Jin, Yaping, Zhang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386245/ https://www.ncbi.nlm.nih.gov/pubmed/25994151 http://dx.doi.org/10.1038/srep10482

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