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Homologous recombination is a force in the evolution of canine distemper virus
Canine distemper virus (CDV) is the causative agent of canine distemper (CD) that is a highly contagious, lethal, multisystemic viral disease of receptive carnivores. The prevalence of CDV is a major concern in susceptible animals. Presently, it is unclear whether intragenic recombination can contri...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386261/ https://www.ncbi.nlm.nih.gov/pubmed/28394936 http://dx.doi.org/10.1371/journal.pone.0175416 |
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author | Yuan, Chaowen Liu, Wenxin Wang, Yingbo Hou, Jinlong Zhang, Liguo Wang, Guoqing |
author_facet | Yuan, Chaowen Liu, Wenxin Wang, Yingbo Hou, Jinlong Zhang, Liguo Wang, Guoqing |
author_sort | Yuan, Chaowen |
collection | PubMed |
description | Canine distemper virus (CDV) is the causative agent of canine distemper (CD) that is a highly contagious, lethal, multisystemic viral disease of receptive carnivores. The prevalence of CDV is a major concern in susceptible animals. Presently, it is unclear whether intragenic recombination can contribute to gene mutations and segment reassortment in the virus. In this study, 25 full-length CDV genome sequences were subjected to phylogenetic and recombinational analyses. The results of phylogenetic analysis, intragenic recombination, and nucleotide selection pressure indicated that mutation and recombination occurred in the six individual genes segment (H, F, P, N, L, M) of the CDV genome. The analysis also revealed pronounced genetic diversity in the CDV genome according to the geographically distinct lineages (genotypes), namely Asia-1, Asia-2, Asia-3, Europe, America-1, and America-2. The six recombination events were detected using SimPlot and RDP programs. The analysis of selection pressure demonstrated that a majority of the nucleotides in the CDV individual gene were under negative selection. Collectively, these data suggested that homologous recombination acts as a key force driving the genetic diversity and evolution of canine distemper virus. |
format | Online Article Text |
id | pubmed-5386261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53862612017-05-03 Homologous recombination is a force in the evolution of canine distemper virus Yuan, Chaowen Liu, Wenxin Wang, Yingbo Hou, Jinlong Zhang, Liguo Wang, Guoqing PLoS One Research Article Canine distemper virus (CDV) is the causative agent of canine distemper (CD) that is a highly contagious, lethal, multisystemic viral disease of receptive carnivores. The prevalence of CDV is a major concern in susceptible animals. Presently, it is unclear whether intragenic recombination can contribute to gene mutations and segment reassortment in the virus. In this study, 25 full-length CDV genome sequences were subjected to phylogenetic and recombinational analyses. The results of phylogenetic analysis, intragenic recombination, and nucleotide selection pressure indicated that mutation and recombination occurred in the six individual genes segment (H, F, P, N, L, M) of the CDV genome. The analysis also revealed pronounced genetic diversity in the CDV genome according to the geographically distinct lineages (genotypes), namely Asia-1, Asia-2, Asia-3, Europe, America-1, and America-2. The six recombination events were detected using SimPlot and RDP programs. The analysis of selection pressure demonstrated that a majority of the nucleotides in the CDV individual gene were under negative selection. Collectively, these data suggested that homologous recombination acts as a key force driving the genetic diversity and evolution of canine distemper virus. Public Library of Science 2017-04-10 /pmc/articles/PMC5386261/ /pubmed/28394936 http://dx.doi.org/10.1371/journal.pone.0175416 Text en © 2017 Yuan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yuan, Chaowen Liu, Wenxin Wang, Yingbo Hou, Jinlong Zhang, Liguo Wang, Guoqing Homologous recombination is a force in the evolution of canine distemper virus |
title | Homologous recombination is a force in the evolution of canine distemper virus |
title_full | Homologous recombination is a force in the evolution of canine distemper virus |
title_fullStr | Homologous recombination is a force in the evolution of canine distemper virus |
title_full_unstemmed | Homologous recombination is a force in the evolution of canine distemper virus |
title_short | Homologous recombination is a force in the evolution of canine distemper virus |
title_sort | homologous recombination is a force in the evolution of canine distemper virus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386261/ https://www.ncbi.nlm.nih.gov/pubmed/28394936 http://dx.doi.org/10.1371/journal.pone.0175416 |
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