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Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2

Ubiquitin ligase von Hippel–Lindau tumor suppressor (pVHL) negatively regulates protein levels of hypoxia-inducible factor-α (HIF-α). Loss of pVHL causes HIF-α accumulation, which contributes to the pathogenesis of von Hippel-Lindau (VHL) disease. In contrast, v-Myb avian myeloblastosis viral oncoge...

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Detalles Bibliográficos
Autores principales:	Okumura, Fumihiko, Joo-Okumura, Akiko, Nakatsukasa, Kunio, Kamura, Takumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386292/ https://www.ncbi.nlm.nih.gov/pubmed/28394947 http://dx.doi.org/10.1371/journal.pone.0175593

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