The role of the extracellular matrix in primary myelofibrosis

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) fibrosis. While cellular mutations involved in the development of PMF have been heavily investigated, noteworthy is the important r...

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Autores principales: Leiva, O, Ng, S K, Chitalia, S, Balduini, A, Matsuura, S, Ravid, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386340/
https://www.ncbi.nlm.nih.gov/pubmed/28157219
http://dx.doi.org/10.1038/bcj.2017.6
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author Leiva, O
Ng, S K
Chitalia, S
Balduini, A
Matsuura, S
Ravid, K
author_facet Leiva, O
Ng, S K
Chitalia, S
Balduini, A
Matsuura, S
Ravid, K
author_sort Leiva, O
collection PubMed
description Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) fibrosis. While cellular mutations involved in the development of PMF have been heavily investigated, noteworthy is the important role the extracellular matrix (ECM) plays in the progression of BM fibrosis. This review surveys ECM proteins contributors of PMF, and highlights how better understanding of the control of the ECM within the BM niche may lead to combined therapeutic options in PMF.
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spelling pubmed-53863402017-04-26 The role of the extracellular matrix in primary myelofibrosis Leiva, O Ng, S K Chitalia, S Balduini, A Matsuura, S Ravid, K Blood Cancer J Review Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) fibrosis. While cellular mutations involved in the development of PMF have been heavily investigated, noteworthy is the important role the extracellular matrix (ECM) plays in the progression of BM fibrosis. This review surveys ECM proteins contributors of PMF, and highlights how better understanding of the control of the ECM within the BM niche may lead to combined therapeutic options in PMF. Nature Publishing Group 2017-02 2017-02-03 /pmc/articles/PMC5386340/ /pubmed/28157219 http://dx.doi.org/10.1038/bcj.2017.6 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review
Leiva, O
Ng, S K
Chitalia, S
Balduini, A
Matsuura, S
Ravid, K
The role of the extracellular matrix in primary myelofibrosis
title The role of the extracellular matrix in primary myelofibrosis
title_full The role of the extracellular matrix in primary myelofibrosis
title_fullStr The role of the extracellular matrix in primary myelofibrosis
title_full_unstemmed The role of the extracellular matrix in primary myelofibrosis
title_short The role of the extracellular matrix in primary myelofibrosis
title_sort role of the extracellular matrix in primary myelofibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386340/
https://www.ncbi.nlm.nih.gov/pubmed/28157219
http://dx.doi.org/10.1038/bcj.2017.6
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