Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies

CD47, a broadly expressed cell surface protein, inhibits cell phagocytosis via interaction with phagocyte-expressed SIRPα. A variety of hematological malignancies demonstrate elevated CD47 expression, suggesting that CD47 may mediate immune escape. We discovered three unique CD47-SIRPα blocking anti...

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Detalles Bibliográficos
Autores principales: Pietsch, E C, Dong, J, Cardoso, R, Zhang, X, Chin, D, Hawkins, R, Dinh, T, Zhou, M, Strake, B, Feng, P-H, Rocca, M, Santos, C Dos, Shan, X, Danet-Desnoyers, G, Shi, F, Kaiser, E, Millar, H J, Fenton, S, Swanson, R, Nemeth, J A, Attar, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386341/
https://www.ncbi.nlm.nih.gov/pubmed/28234345
http://dx.doi.org/10.1038/bcj.2017.7

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