The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells

Disease recurrence is the major problem in the treatment of acute myeloid leukemia (AML). Relapse is driven by leukemia stem cells, a chemoresistant subpopulation capable of re-establishing disease. Patients with p53 mutant AML are at an extremely high risk of relapse. B-cell-specific Moloney murine...

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Detalles Bibliográficos
Autores principales: Nishida, Y, Maeda, A, Kim, M J, Cao, L, Kubota, Y, Ishizawa, J, AlRawi, A, Kato, Y, Iwama, A, Fujisawa, M, Matsue, K, Weetall, M, Dumble, M, Andreeff, M, Davis, T W, Branstrom, A, Kimura, S, Kojima, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386342/
https://www.ncbi.nlm.nih.gov/pubmed/28211885
http://dx.doi.org/10.1038/bcj.2017.8

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