Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation

Aberrant Sumoylation of protein(s) in response to oxidative stress or during aging is known to be involved in etiopathogenesis of many diseases. Upon oxidative stress, Peroxiredoxin (Prdx) 6 is aberrantly Sumoylated by Sumo1, resulting in loss of functions and cell death. We identified lysines (K) 1...

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Detalles Bibliográficos
Autores principales: Chhunchha, Bhavana, Kubo, Eri, Fatma, Nigar, Singh, Dhirendra P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386354/
https://www.ncbi.nlm.nih.gov/pubmed/28055018
http://dx.doi.org/10.1038/cddis.2016.424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386354/
https://www.ncbi.nlm.nih.gov/pubmed/28055018
http://dx.doi.org/10.1038/cddis.2016.424

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