Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a ma...

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Detalles Bibliográficos
Autores principales: Ugun-Klusek, Aslihan, Tatham, Michael H, Elkharaz, Jamal, Constantin-Teodosiu, Dumitru, Lawler, Karen, Mohamed, Hala, Paine, Simon M L, Anderson, Glen, John Mayer, R, Lowe, James, Ellen Billett, E, Bedford, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386360/
https://www.ncbi.nlm.nih.gov/pubmed/28055010
http://dx.doi.org/10.1038/cddis.2016.443

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