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Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim

Cellular acetylation homeostasis is a kinetic balance precisely controlled by histone acetyl-transferase (HAT) and histone deacetylase (HDAC) activities. The loss of the counterbalancing function of basal HAT activity alters the precious HAT:HDAC balance towards enhanced histone deacetylation, resul...

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Detalles Bibliográficos
Autores principales:	Wu, Yanna, Ma, Shanshan, Xia, Yong, Lu, Yangpeng, Xiao, Shiyin, Cao, Yali, Zhuang, Sidian, Tan, Xiangpeng, Fu, Qiang, Xie, Longchang, Li, Zhiming, Yuan, Zhongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386373/ https://www.ncbi.nlm.nih.gov/pubmed/28125090 http://dx.doi.org/10.1038/cddis.2016.465

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