Cargando…

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

Human immunodeficiency virus-associated neurological disorders (HANDs) affect the majority of AIDS patients and are a significant problem among HIV-1-infected individuals who live longer because of combined anti-retroviral therapies. HIV-1 utilizes a number of viral proteins and subsequent cytokine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sami Saribas, A, Cicalese, Stephanie, Ahooyi, Taha Mohseni, Khalili, Kamel, Amini, Shohreh, Sariyer, Ilker Kudret
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386374/ https://www.ncbi.nlm.nih.gov/pubmed/28079886 http://dx.doi.org/10.1038/cddis.2016.467

Ejemplares similares

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein
por: Torkzaban, Bahareh, et al.
Publicado: (2020)

Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials
por: Vakili, Sarah, et al.
Publicado: (2020)

Characterization of Nef expression in different brain regions of SIV-infected macaques
por: Yarandi, Shadan S., et al.
Publicado: (2020)

HIV-1 Nef blocks autophagy in human astrocytes
por: Sardo, Luca, et al.
Publicado: (2015)

Regulation of Human Neurotropic JC Virus Replication by Alternative Splicing Factor SF2/ASF in Glial Cells
por: Sariyer, Ilker Kudret, et al.
Publicado: (2011)

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses
por: McNamara, Ryan P., et al.
Publicado: (2018)

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy
por: Gupta, Manish K., et al.
Publicado: (2017)

HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes
por: Wilson, Kelly M., et al.
Publicado: (2023)

Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells
por: Dubrovsky, Larisa, et al.
Publicado: (2022)

HIV-1 Nef: at the crossroads
por: Foster, John L, et al.
Publicado: (2008)

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities
por: Martínez-Bonet, Marta, et al.
Publicado: (2015)

HIV-1 release requires Nef-induced caspase activation
por: Segura, Jason, et al.
Publicado: (2023)

HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide
por: Masanetz, Sabine, et al.
Publicado: (2011)

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages
por: Mwimanzi, Philip, et al.
Publicado: (2011)

JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells
por: Noch, Evan, et al.
Publicado: (2012)

Self-association of the Lentivirus protein, Nef
por: Kwak, Youn Tae, et al.
Publicado: (2010)

The activity of Nef on HIV-1 infectivity
por: Basmaciogullari, Stéphane, et al.
Publicado: (2014)

The NeuroinflammatoryPotential of HIV-1 NefVariants in Modulating the Gene Expression Profile of Astrocytes
por: Jadhav, Sushama, et al.
Publicado: (2022)

The C-Terminal Domain of Nef(mut) Is Dispensable for the CD8(+) T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2021)

Protein cargo of Nef-containing exosomal extracellular vesicles may predict HIV-associated Neurocognitive Impairment status
por: Caobi, Allen, et al.
Publicado: (2023)

HIV-1 Nef targets calnexin: a novel mechanism behind Nef effects on host cell and viral proteins
por: Jennelle, Lucas, et al.
Publicado: (2013)

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
por: Naicker, Delon, et al.
Publicado: (2023)

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection
por: Lee, Jung-Hyun, et al.
Publicado: (2016)

N-Terminal Fatty Acids of NEF(MUT) Are Required for the CD8(+) T-Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2020)

Nef-mediated Clathrin-coated Pit Formation
por: Foti, Michelangelo, et al.
Publicado: (1997)

Exosomes Are Unlikely Involved in Intercellular Nef Transfer
por: Luo, Xiaoyu, et al.
Publicado: (2015)

TNF and HIV-1 Nef: An Intimate Interplay
por: Herbein, Georges
Publicado: (2016)

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis
por: Serra-Moreno, Ruth, et al.
Publicado: (2013)

Genetic defects in the nef gene are associated with Korean Red Ginseng intake: monitoring of nef sequence polymorphisms over 20 years
por: Cho, Young-Keol, et al.
Publicado: (2017)

Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells
por: Mohseni Ahooyi, Taha, et al.
Publicado: (2019)

Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing
por: Mohseni Ahooyi, Taha, et al.
Publicado: (2018)

HIV-1 Nef Protein Affects Cytokine and Extracellular Vesicles Production in the GEN2.2 Plasmacytoid Dendritic Cell Line
por: Aiello, Alessandra, et al.
Publicado: (2021)

Chemotactic activity of HIV-1 Nef for human monocytes
por: Lehmann, MH, et al.
Publicado: (2006)

The Nef-Infectivity Enigma: Mechanisms of Enhanced Lentiviral Infection
por: Vermeire, Jolien, et al.
Publicado: (2011)

Understanding the nature of the Nef requirement for HIV-1 infectivity
por: Rosa, Annachiara, et al.
Publicado: (2013)

Neuromorphic NEF-Based Inverse Kinematics and PID Control
por: Zaidel, Yuval, et al.
Publicado: (2021)

Synergy and allostery in ligand binding by HIV-1 Nef
por: Aldehaiman, Abdullah, et al.
Publicado: (2021)

Add-on-LUCAS2™-Reanimation am NEF Innsbruck
por: Schwaiger, D., et al.
Publicado: (2022)

Hsp70-nucleotide exchange factor (NEF) Fes1 has non-NEF roles in degradation of gluconeogenic enzymes and cell wall integrity
por: Kumar, Shailesh, et al.
Publicado: (2019)

Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and H(2)O(2): implications for HIV-associated neurological disorders
por: Duggan, Michael R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_glqcilqjtf3fohqo9h6ifs0sl2