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Mitochondrial respiratory dysfunction disturbs neuronal and cardiac lineage commitment of human iPSCs

Mitochondrial diseases are genetically heterogeneous and present a broad clinical spectrum among patients; in most cases, genetic determinants of mitochondrial diseases are heteroplasmic mitochondrial DNA (mtDNA) mutations. However, it is uncertain whether and how heteroplasmic mtDNA mutations affec...

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Detalles Bibliográficos
Autores principales:	Yokota, Mutsumi, Hatakeyama, Hideyuki, Ono, Yasuha, Kanazawa, Miyuki, Goto, Yu-ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386384/ https://www.ncbi.nlm.nih.gov/pubmed/28079893 http://dx.doi.org/10.1038/cddis.2016.484

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