Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells

DNA damage-induced apoptosis suppressor (DDIAS) rescues lung cancer cells from apoptosis in response to DNA damage. DDIAS is transcriptionally activated by NFATc1 and EGF-mediated ERK5/MEF2B, leading to cisplatin resistance and cell invasion. Therefore, DDIAS is suggested as a therapeutic target for...

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Detalles Bibliográficos
Autores principales: Won, Kyoung-Jae, Im, Joo-Young, Kim, Bo-Kyung, Ban, Hyun Seung, Jung, Young-Jin, Jung, Kyeong Eun, Won, Misun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386388/
https://www.ncbi.nlm.nih.gov/pubmed/28079882
http://dx.doi.org/10.1038/cddis.2016.488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386388/
https://www.ncbi.nlm.nih.gov/pubmed/28079882
http://dx.doi.org/10.1038/cddis.2016.488

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