Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis

Delocalized lipophilic cations (DLCs) selectively accumulate in cancer cell mitochondria and have long been explored for therapeutic applications. Although targeted effects to cancer cells are demonstrated in vitro, non-specific toxicities in vivo have hampered clinical development. Identifying the...

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Detalles Bibliográficos
Autores principales: Yang, Ning, Weinfeld, Michael, Lemieux, Hélène, Montpetit, Ben, Goping, Ing Swie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386467/
https://www.ncbi.nlm.nih.gov/pubmed/28151485
http://dx.doi.org/10.1038/cddis.2017.19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386467/
https://www.ncbi.nlm.nih.gov/pubmed/28151485
http://dx.doi.org/10.1038/cddis.2017.19

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