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Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis
Delocalized lipophilic cations (DLCs) selectively accumulate in cancer cell mitochondria and have long been explored for therapeutic applications. Although targeted effects to cancer cells are demonstrated in vitro, non-specific toxicities in vivo have hampered clinical development. Identifying the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386467/ https://www.ncbi.nlm.nih.gov/pubmed/28151485 http://dx.doi.org/10.1038/cddis.2017.19 |