RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL). The kinase of RIPK3 phosphorylates MLKL causing MLKL to form a pore-like structure, allowing intracellular contents to r...

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Detalles Bibliográficos
Autores principales: Hänggi, Kay, Vasilikos, Lazaros, Valls, Aida Freire, Yerbes, Rosario, Knop, Janin, Spilgies, Lisanne M, Rieck, Kristy, Misra, Tvisha, Bertin, John, Gough, Peter J, Schmidt, Thomas, de Almodòvar, Carmen Ruiz, Wong, W Wei-Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386469/
https://www.ncbi.nlm.nih.gov/pubmed/28151480
http://dx.doi.org/10.1038/cddis.2017.20

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