Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes

Our previous study and others have demonstrated that autophagy is activated in ischemic astrocytes and contributes to astrocytic cell death. However, the mechanisms of ischemia-induced autophagy remain largely unknown. In this study, we established a rat's model of permanent middle cerebral art...

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Detalles Bibliográficos
Autores principales: Zhou, Xian-Yong, Luo, Yu, Zhu, Yong-Ming, Liu, Zhi-He, Kent, Thomas A, Rong, Jia-Guo, Li, Wei, Qiao, Shi-Gang, Li, Min, Ni, Yong, Ishidoh, Kazumi, Zhang, Hui-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386481/
https://www.ncbi.nlm.nih.gov/pubmed/28206988
http://dx.doi.org/10.1038/cddis.2017.34

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