Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

The antitumor effect of luteolin, a plant flavonoid, in gastric cancer (GC) cells has not been fully understood. Here we show that luteolin selectively kills STAT3 overactivated GC cells that are often drug resistant. The treatment of luteolin in these GC cells significantly inhibited STAT3 phosphor...

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Detalles Bibliográficos
Autores principales: Song, Shiyu, Su, Zhonglan, Xu, Hui, Niu, Mengyuan, Chen, Xiufang, Min, Haiyan, Zhang, Bin, Sun, Guibo, Xie, Sijing, Wang, Hongwei, Gao, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386483/
https://www.ncbi.nlm.nih.gov/pubmed/28182003
http://dx.doi.org/10.1038/cddis.2017.38

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