NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC

Transforming growth factor-beta (TGF-β) signaling has gained extensive interest in hepatocellular carcinoma (HCC). The small molecule kinase inhibitor galunisertib, targeting the TGF-β receptor I (TGF-βRI), blocks HCC progression in preclinical models and shows promising effects in ongoing clinical...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Yuan, Agarwal, Rahul, Dituri, Francesco, Lupo, Luigi, Trerotoli, Paolo, Mancarella, Serena, Winter, Peter, Giannelli, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386488/
https://www.ncbi.nlm.nih.gov/pubmed/28230858
http://dx.doi.org/10.1038/cddis.2017.44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386488/
https://www.ncbi.nlm.nih.gov/pubmed/28230858
http://dx.doi.org/10.1038/cddis.2017.44

Ejemplares similares