Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4

Coordination of energy metabolism is essential for homeostasis of stem cells, whereas an imbalance in energy homeostasis causes disease and accelerated aging. Here we show that deletion or enzymatic inactivation of lysine-specific demethylase 1 (Lsd1) triggers senescence in trophoblast stem cells (T...

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Detalles Bibliográficos
Autores principales: Castex, Josefina, Willmann, Dominica, Kanouni, Toufike, Arrigoni, Laura, Li, Yan, Friedrich, Marcel, Schleicher, Michael, Wöhrle, Simon, Pearson, Mark, Kraut, Norbert, Méret, Michaël, Manke, Thomas, Metzger, Eric, Schüle, Roland, Günther, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386490/
https://www.ncbi.nlm.nih.gov/pubmed/28230862
http://dx.doi.org/10.1038/cddis.2017.48

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