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Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner

The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and can induce secondary malignancies. Thus, the clinica...

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Detalles Bibliográficos
Autores principales:	Alexandrova, Evguenia M, Xu, Sulan, Moll, Ute M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386516/ https://www.ncbi.nlm.nih.gov/pubmed/28300840 http://dx.doi.org/10.1038/cddis.2017.108

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