PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407

Colorectal cancer (CRC) is the third most common cause of cancer deaths, and has a high rate of liver and lung metastasis. Unfortunately, distant metastasis is the main barrier for advanced CRC therapy and leads to a very low survival rate. In this study, we identified WDR5, a vital factor that regu...

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Detalles Bibliográficos
Autores principales: Tan, Xin, Chen, Shuai, Wu, Jiangxue, Lin, Jiaxin, Pan, Changchuan, Ying, Xiaofang, Pan, Zhizhong, Qiu, Lin, Liu, Ranyi, Geng, Rong, Huang, Wenlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386518/
https://www.ncbi.nlm.nih.gov/pubmed/28300833
http://dx.doi.org/10.1038/cddis.2017.111

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