Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

The current agents used for renal cell carcinoma (RCC) only exhibit the moderate response rate among patients. Development of drug resistance eventually fuels the need of either more potent drugs or new drugs to target the resistant pathways. Oridonin is a diterpenoid isolated from the Chinese medic...

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Detalles Bibliográficos
Autores principales: Zhou, Jiancheng, Yun, Eun-Jin, Chen, Wei, Ding, Ye, Wu, Kaijie, Wang, Bin, Ding, Chunyong, Hernandez, Elizabeth, Santoyo, John, Pong, Rey-Chen, Chen, Haiying, He, Dalin, Zhou, Jia, Hsieh, Jer-Tsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386527/
https://www.ncbi.nlm.nih.gov/pubmed/28333136
http://dx.doi.org/10.1038/cddis.2017.121

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