Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death

Owing to lagging or insufficient neo-angiogenesis, hypoxia is a feature of most solid tumors. Hypoxic tumor regions contribute to resistance against antiproliferative chemotherapeutics, radiotherapy and immunotherapy. Targeting cells in hypoxic tumor areas is therefore an important strategy for canc...

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Detalles Bibliográficos
Autores principales: Klutzny, Saskia, Lesche, Ralf, Keck, Matthias, Kaulfuss, Stefan, Schlicker, Andreas, Christian, Sven, Sperl, Carolyn, Neuhaus, Roland, Mowat, Jeffrey, Steckel, Michael, Riefke, Björn, Prechtl, Stefan, Parczyk, Karsten, Steigemann, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386533/
https://www.ncbi.nlm.nih.gov/pubmed/28358364
http://dx.doi.org/10.1038/cddis.2017.130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386533/
https://www.ncbi.nlm.nih.gov/pubmed/28358364
http://dx.doi.org/10.1038/cddis.2017.130

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