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Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines

The use of tumor-treating fields (TTFields) has revolutionized the treatment of recurrent and newly diagnosed glioblastoma (GBM). TTFields are low-intensity, intermediate frequency, alternating electric fields that are applied to tumor regions and cells using non-invasive arrays. The predominant mec...

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Detalles Bibliográficos
Autores principales:	Karanam, Narasimha Kumar, Srinivasan, Kalayarasan, Ding, Lianghao, Sishc, Brock, Saha, Debabrata, Story, Michael D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386539/ https://www.ncbi.nlm.nih.gov/pubmed/28358361 http://dx.doi.org/10.1038/cddis.2017.136

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