Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

The imbalance between Th17 and Treg cells substantially contributes to the intestinal immune disturbance and subsequent tissue injury in ulcerative colitis. The triterpenoid-rich fraction of Centella asiatica was able to ameliorate dextran sulfate sodium-induced colitis in mice. Here we explored its...

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Detalles Bibliográficos
Autores principales: Xu, Xiaotian, Wang, Yuhui, Wei, Zhifeng, Wei, Wenhui, Zhao, Peng, Tong, Bei, Xia, Yufeng, Dai, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386545/
https://www.ncbi.nlm.nih.gov/pubmed/28358365
http://dx.doi.org/10.1038/cddis.2017.150

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