Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth

Loss or dysfunction of tumor suppressor retinoblastoma (RB) is a common feature in various tumors, and contributes to cancer cell stemness and drug resistance to cancer therapy. However, the strategy to suppress or eliminate Rb-deficient tumor cells remains unclear. In the present study, we accident...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Juan, Liu, Jie, Liang, Zheyong, He, Fang, Yang, Lu, Li, Pingping, Jiang, Yina, Wang, Bo, Zhou, Can, Wang, Yaochun, Ren, Yu, Yang, Jin, Zhang, Jianmin, Luo, Zhijun, Vaziri, Cyrus, Liu, Peijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386551/
https://www.ncbi.nlm.nih.gov/pubmed/28300827
http://dx.doi.org/10.1038/cddis.2017.46

Ejemplares similares

Ejemplares similares