p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo

Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metast...

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Detalles Bibliográficos
Autores principales: Alexandrova, Evguenia M, Mirza, Safia A, Xu, Sulan, Schulz-Heddergott, Ramona, Marchenko, Natalia D, Moll, Ute M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386572/
https://www.ncbi.nlm.nih.gov/pubmed/28277540
http://dx.doi.org/10.1038/cddis.2017.80

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