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CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

CD95 is best known for its ability to induce apoptosis via a well-characterized pathway involving caspase-mediated proteolytic events. However, in apoptosis-resistant cell lines of diverse cancer types stimulation of CD95 primarily has pro-tumorigenic effects that affect many of the hallmarks of can...

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Detalles Bibliográficos
Autores principales:	Raats, Danielle A, Frenkel, Nicola, van Schelven, Susanne J, Rinkes, Inne HMBorel, Laoukili, Jamila, Kranenburg, Onno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386578/ https://www.ncbi.nlm.nih.gov/pubmed/28300842 http://dx.doi.org/10.1038/cddis.2017.87

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