Systematic morphological profiling of human gene and allele function via Cell Painting

We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220 tested genes yielded detectable morphological profiles, which grouped in...

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Detalles Bibliográficos
Autores principales: Rohban, Mohammad Hossein, Singh, Shantanu, Wu, Xiaoyun, Berthet, Julia B, Bray, Mark-Anthony, Shrestha, Yashaswi, Varelas, Xaralabos, Boehm, Jesse S, Carpenter, Anne E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386591/
https://www.ncbi.nlm.nih.gov/pubmed/28315521
http://dx.doi.org/10.7554/eLife.24060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386591/
https://www.ncbi.nlm.nih.gov/pubmed/28315521
http://dx.doi.org/10.7554/eLife.24060

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