Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells

Glutaminolysis is important for metabolism and biosynthesis of cancer cells, and GLS is essential in the process. Selenite is widely regarded as a chemopreventive agent against cancer risk. Emerging evidence suggests that it also has chemotherapeutic potential in various cancer types, but the mechan...

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Detalles Bibliográficos
Autores principales: Zhao, Junzhang, Zhou, Rui, Hui, Kaiyuan, Yang, Yang, Zhang, QiuYue, Ci, Yali, Shi, Lei, Xu, Caimin, Huang, Fang, Hu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386651/
https://www.ncbi.nlm.nih.gov/pubmed/27902968
http://dx.doi.org/10.18632/oncotarget.13600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386651/
https://www.ncbi.nlm.nih.gov/pubmed/27902968
http://dx.doi.org/10.18632/oncotarget.13600

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