IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells

Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the t...

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Detalles Bibliográficos
Autores principales: Bie, Qingli, Zhang, Bin, Sun, Caixia, Ji, Xiaoyun, Barnie, Prince Amoah, Qi, Chen, Peng, Jingjing, Zhang, Danyi, Zheng, Dong, Su, Zhaoliang, Wang, Shengjun, Xu, Huaxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386657/
https://www.ncbi.nlm.nih.gov/pubmed/28145881
http://dx.doi.org/10.18632/oncotarget.14835
Descripción
Sumario:Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression. The results showed that IL-17B induced the expression of stemness-related genes Nanog, Sox2, and Oct4 in mesenchymal stem cells and enhanced its tumor-promoting effect. The supernatant from cultured mesenchymal stem cells after treating with exogenous rIL-17B promoted the proliferation and migration of MGC-803, therefor suggesting that rIL-17B might promote mesenchymal stem cells to produce soluble factors. In addition, rIL-17B also activated the NF-κΒ, STAT3, β-catenin pathway in mesenchymal stem cells. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells.

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