Cargando…

Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer

ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not clear. Here we generated an Adamts18-deficient mouse strain as an in vivo model to investigate the role of ADAMTS18 in the pathogenesis of colorectal cancer. In...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Tiantian, Dang, Suying, Zhu, Rui, Wang, Ying, Nie, Zongying, Hong, Tao, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386663/
https://www.ncbi.nlm.nih.gov/pubmed/28145888
http://dx.doi.org/10.18632/oncotarget.14866