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Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer

ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not clear. Here we generated an Adamts18-deficient mouse strain as an in vivo model to investigate the role of ADAMTS18 in the pathogenesis of colorectal cancer. In...

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Detalles Bibliográficos
Autores principales:	Lu, Tiantian, Dang, Suying, Zhu, Rui, Wang, Ying, Nie, Zongying, Hong, Tao, Zhang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386663/ https://www.ncbi.nlm.nih.gov/pubmed/28145888 http://dx.doi.org/10.18632/oncotarget.14866

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