Inhibition of ALDH2 by O-GlcNAcylation contributes to the hyperglycemic exacerbation of myocardial ischemia/reperfusion injury

Although hyperglycemia is causally related to adverse outcomes after myocardial ischemia/reperfusion (I/R), the underlying mechanisms are largely unknown. Here, we investigated whether excessive O-linked-N-acetylglucosamine (O-GlcNAc) modification of acetaldehyde dehydrogenase 2 (ALDH2), an importan...

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Detalles Bibliográficos
Autores principales: Liu, Baoshan, Wang, Jiali, Li, Minghua, Yuan, Qiuhuan, Xue, Mengyang, Xu, Feng, Chen, Yuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386694/
https://www.ncbi.nlm.nih.gov/pubmed/28038474
http://dx.doi.org/10.18632/oncotarget.14297

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