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MDM4 genetic variants and risk of gastric cancer in an eastern chinese population
MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (SNPs) (rs11801299 G>A, rs1380576 C>G an...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386704/ https://www.ncbi.nlm.nih.gov/pubmed/28099948 http://dx.doi.org/10.18632/oncotarget.14666 |
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author | Wang, Meng-Yun Jia, Ming He, Jing Zhou, Fei Qiu, Li-Xin Sun, Meng-Hong Yang, Ya-Jun Wang, Jiu-Cun Jin, Li Wang, Ya-Nong Wei, Qing-Yi |
author_facet | Wang, Meng-Yun Jia, Ming He, Jing Zhou, Fei Qiu, Li-Xin Sun, Meng-Hong Yang, Ya-Jun Wang, Jiu-Cun Jin, Li Wang, Ya-Nong Wei, Qing-Yi |
author_sort | Wang, Meng-Yun |
collection | PubMed |
description | MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (SNPs) (rs11801299 G>A, rs1380576 C>G and rs10900598 G>T) in MDM4 and gastric cancer risk in an Eastern Chinese Population. In logistic regression analysis, a significantly decreased GCa risk was associated with the rs1380576 GG variant genotype (adjusted odds ratio [OR] =0.74, 95% confidence interval [CI] =0.56-0.98) under a recessive model, which remained significant after correction by the false-positive reporting probability. This risk was more evident in subgroups of older subjects, males, never smokers, never drinkers and cancers of non-cardia. We then performed SNP-mRNA expression correlation analysis and found that the GG variant genotype was associated with significantly decreased expression of MDM4 mRNA in normal cell lines for 44 Chinese (P=0.032 for GG vs. CC) as well as for 269 multi-ethnic subjects (P<0.0001 for GG vs. CC). Our results suggest that the MDM4 rs1380576 G variant may be markers for GCa susceptibility. Larger, independent studies are warranted to validate our findings. |
format | Online Article Text |
id | pubmed-5386704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53867042017-04-26 MDM4 genetic variants and risk of gastric cancer in an eastern chinese population Wang, Meng-Yun Jia, Ming He, Jing Zhou, Fei Qiu, Li-Xin Sun, Meng-Hong Yang, Ya-Jun Wang, Jiu-Cun Jin, Li Wang, Ya-Nong Wei, Qing-Yi Oncotarget Research Paper MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (SNPs) (rs11801299 G>A, rs1380576 C>G and rs10900598 G>T) in MDM4 and gastric cancer risk in an Eastern Chinese Population. In logistic regression analysis, a significantly decreased GCa risk was associated with the rs1380576 GG variant genotype (adjusted odds ratio [OR] =0.74, 95% confidence interval [CI] =0.56-0.98) under a recessive model, which remained significant after correction by the false-positive reporting probability. This risk was more evident in subgroups of older subjects, males, never smokers, never drinkers and cancers of non-cardia. We then performed SNP-mRNA expression correlation analysis and found that the GG variant genotype was associated with significantly decreased expression of MDM4 mRNA in normal cell lines for 44 Chinese (P=0.032 for GG vs. CC) as well as for 269 multi-ethnic subjects (P<0.0001 for GG vs. CC). Our results suggest that the MDM4 rs1380576 G variant may be markers for GCa susceptibility. Larger, independent studies are warranted to validate our findings. Impact Journals LLC 2017-01-14 /pmc/articles/PMC5386704/ /pubmed/28099948 http://dx.doi.org/10.18632/oncotarget.14666 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wang, Meng-Yun Jia, Ming He, Jing Zhou, Fei Qiu, Li-Xin Sun, Meng-Hong Yang, Ya-Jun Wang, Jiu-Cun Jin, Li Wang, Ya-Nong Wei, Qing-Yi MDM4 genetic variants and risk of gastric cancer in an eastern chinese population |
title | MDM4 genetic variants and risk of gastric cancer in an eastern chinese population |
title_full | MDM4 genetic variants and risk of gastric cancer in an eastern chinese population |
title_fullStr | MDM4 genetic variants and risk of gastric cancer in an eastern chinese population |
title_full_unstemmed | MDM4 genetic variants and risk of gastric cancer in an eastern chinese population |
title_short | MDM4 genetic variants and risk of gastric cancer in an eastern chinese population |
title_sort | mdm4 genetic variants and risk of gastric cancer in an eastern chinese population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386704/ https://www.ncbi.nlm.nih.gov/pubmed/28099948 http://dx.doi.org/10.18632/oncotarget.14666 |
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