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Role of caspases in CD95-induced biphasic activation of acid sphingomyelinase

Acid sphingomyelinase (A-SMase) plays an important role in the initiation of CD95 signaling by forming ceramide-enriched membrane domains that enable clustering and activation of the death receptors. In TNF-R1 and TRAIL-R1/R2 signaling, A-SMase also contributes to the lysosomal apoptosis pathway tri...

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Detalles Bibliográficos
Autores principales:	Stephan, Mario, Edelmann, Bärbel, Winoto-Morbach, Supandi, Janssen, Ottmar, Bertsch, Uwe, Perrotta, Cristiana, Schütze, Stefan, Fritsch, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386744/ https://www.ncbi.nlm.nih.gov/pubmed/28223543 http://dx.doi.org/10.18632/oncotarget.15379

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