Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies

The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a “caretaker” gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angioge...

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Detalles Bibliográficos
Autores principales: Feng, Yuanyuan, Zhou, Lihong, Sun, Xiaoting, Li, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386776/
https://www.ncbi.nlm.nih.gov/pubmed/28107201
http://dx.doi.org/10.18632/oncotarget.14723
Descripción
Sumario:The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a “caretaker” gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis and attenuation of multidrug resistance in cancer. Additionally, we summarize conditions or factors that may increase HIPK2 activity.

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