Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies

The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a “caretaker” gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angioge...

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Detalles Bibliográficos
Autores principales: Feng, Yuanyuan, Zhou, Lihong, Sun, Xiaoting, Li, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386776/
https://www.ncbi.nlm.nih.gov/pubmed/28107201
http://dx.doi.org/10.18632/oncotarget.14723
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author Feng, Yuanyuan
Zhou, Lihong
Sun, Xiaoting
Li, Qi
author_facet Feng, Yuanyuan
Zhou, Lihong
Sun, Xiaoting
Li, Qi
author_sort Feng, Yuanyuan
collection PubMed
description The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a “caretaker” gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis and attenuation of multidrug resistance in cancer. Additionally, we summarize conditions or factors that may increase HIPK2 activity.
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spelling pubmed-53867762017-04-26 Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies Feng, Yuanyuan Zhou, Lihong Sun, Xiaoting Li, Qi Oncotarget Review The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a “caretaker” gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis and attenuation of multidrug resistance in cancer. Additionally, we summarize conditions or factors that may increase HIPK2 activity. Impact Journals LLC 2017-01-18 /pmc/articles/PMC5386776/ /pubmed/28107201 http://dx.doi.org/10.18632/oncotarget.14723 Text en Copyright: © 2017 Feng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Feng, Yuanyuan
Zhou, Lihong
Sun, Xiaoting
Li, Qi
Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies
title Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies
title_full Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies
title_fullStr Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies
title_full_unstemmed Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies
title_short Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies
title_sort homeodomain-interacting protein kinase 2 (hipk2): a promising target for anti-cancer therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386776/
https://www.ncbi.nlm.nih.gov/pubmed/28107201
http://dx.doi.org/10.18632/oncotarget.14723
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