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Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant

Drug resistance is a consequence of how most modern medicines work. Drugs exert pressure on cells that causes death or the evolution of resistance. Indeed, highly specific drugs are rendered ineffective by a single DNA mutation. In this study, we apply the drug methotrexate, which is widely used in...

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Detalles Bibliográficos
Autores principales:	Wong, Lai H., Flibotte, Stephane, Sinha, Sunita, Chiang, Jennifer, Giaever, Guri, Nislow, Corey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2017
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386873/ https://www.ncbi.nlm.nih.gov/pubmed/28235825 http://dx.doi.org/10.1534/g3.116.038117

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