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Antitumor activity of chLpMab‐2, a human–mouse chimeric cancer‐specific antihuman podoplanin antibody, via antibody‐dependent cellular cytotoxicity

Human podoplanin (hPDPN), a platelet aggregation‐inducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to C‐type lectin‐like receptor 2 (CLEC‐2). The overexpression of hPDPN is involved in invasion and metastasis. Anti‐hPDPN monoclonal antibodies (mAbs) such as...

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Detalles Bibliográficos
Autores principales:	Kaneko, Mika K., Yamada, Shinji, Nakamura, Takuro, Abe, Shinji, Nishioka, Yasuhiko, Kunita, Akiko, Fukayama, Masashi, Fujii, Yuki, Ogasawara, Satoshi, Kato, Yukinari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387135/ https://www.ncbi.nlm.nih.gov/pubmed/28332312 http://dx.doi.org/10.1002/cam4.1049

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