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The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma

Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria...

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Autores principales: Park, Eun‐Ran, Kim, Sang‐Bum, Lee, Jee‐San, Kim, Yang‐Hyun, Lee, Dong‐Hyoung, Cho, Eung‐Ho, Park, Sun‐Hoo, Han, Chul Ju, Kim, Bu‐Yeo, Choi, Dong Wook, Yoo, Young Do, Yu, Ami, Lee, Jae Won, Jang, Ja June, Park, Young Nyun, Suh, Kyung‐Suk, Lee, Kee‐Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387164/
https://www.ncbi.nlm.nih.gov/pubmed/28332314
http://dx.doi.org/10.1002/cam4.1042
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author Park, Eun‐Ran
Kim, Sang‐Bum
Lee, Jee‐San
Kim, Yang‐Hyun
Lee, Dong‐Hyoung
Cho, Eung‐Ho
Park, Sun‐Hoo
Han, Chul Ju
Kim, Bu‐Yeo
Choi, Dong Wook
Yoo, Young Do
Yu, Ami
Lee, Jae Won
Jang, Ja June
Park, Young Nyun
Suh, Kyung‐Suk
Lee, Kee‐Ho
author_facet Park, Eun‐Ran
Kim, Sang‐Bum
Lee, Jee‐San
Kim, Yang‐Hyun
Lee, Dong‐Hyoung
Cho, Eung‐Ho
Park, Sun‐Hoo
Han, Chul Ju
Kim, Bu‐Yeo
Choi, Dong Wook
Yoo, Young Do
Yu, Ami
Lee, Jae Won
Jang, Ja June
Park, Young Nyun
Suh, Kyung‐Suk
Lee, Kee‐Ho
author_sort Park, Eun‐Ran
collection PubMed
description Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real‐time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen. UQCRH was frequently overexpressed in HCC tissues (46.8%, based on 2.1‐fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion. Kaplan–Meier analysis revealed significantly shorter overall (P = 0.005) and recurrence‐free survival (P = 0.027) in patients with tumors overexpressing UQCRH. The prognostic impact of UQCRH was significant in subgroups of patients divided according to the α‐fetoprotein (AFP) level. The patient subgroup with higher AFP levels (≥20 ng/mL) exhibited significant differences in 5‐year overall (18.5% vs. 67.9%) and recurrence‐free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP levels (<20 ng/mL). Multivariate analysis defined UQCRH as an independent poor prognostic factor. Conclusively, our results indicate that UQCRH overexpression is correlated with poor outcomes of HCC patients. Furthermore, in patients grouped as high risk based on elevated AFP, lack of UQCRH overexpression could be a useful indicator for clinical treatment.
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spelling pubmed-53871642017-04-14 The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma Park, Eun‐Ran Kim, Sang‐Bum Lee, Jee‐San Kim, Yang‐Hyun Lee, Dong‐Hyoung Cho, Eung‐Ho Park, Sun‐Hoo Han, Chul Ju Kim, Bu‐Yeo Choi, Dong Wook Yoo, Young Do Yu, Ami Lee, Jae Won Jang, Ja June Park, Young Nyun Suh, Kyung‐Suk Lee, Kee‐Ho Cancer Med Clinical Cancer Research Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real‐time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen. UQCRH was frequently overexpressed in HCC tissues (46.8%, based on 2.1‐fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion. Kaplan–Meier analysis revealed significantly shorter overall (P = 0.005) and recurrence‐free survival (P = 0.027) in patients with tumors overexpressing UQCRH. The prognostic impact of UQCRH was significant in subgroups of patients divided according to the α‐fetoprotein (AFP) level. The patient subgroup with higher AFP levels (≥20 ng/mL) exhibited significant differences in 5‐year overall (18.5% vs. 67.9%) and recurrence‐free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP levels (<20 ng/mL). Multivariate analysis defined UQCRH as an independent poor prognostic factor. Conclusively, our results indicate that UQCRH overexpression is correlated with poor outcomes of HCC patients. Furthermore, in patients grouped as high risk based on elevated AFP, lack of UQCRH overexpression could be a useful indicator for clinical treatment. John Wiley and Sons Inc. 2017-03-23 /pmc/articles/PMC5387164/ /pubmed/28332314 http://dx.doi.org/10.1002/cam4.1042 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Park, Eun‐Ran
Kim, Sang‐Bum
Lee, Jee‐San
Kim, Yang‐Hyun
Lee, Dong‐Hyoung
Cho, Eung‐Ho
Park, Sun‐Hoo
Han, Chul Ju
Kim, Bu‐Yeo
Choi, Dong Wook
Yoo, Young Do
Yu, Ami
Lee, Jae Won
Jang, Ja June
Park, Young Nyun
Suh, Kyung‐Suk
Lee, Kee‐Ho
The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
title The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
title_full The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
title_fullStr The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
title_full_unstemmed The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
title_short The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
title_sort mitochondrial hinge protein, uqcrh, is a novel prognostic factor for hepatocellular carcinoma
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387164/
https://www.ncbi.nlm.nih.gov/pubmed/28332314
http://dx.doi.org/10.1002/cam4.1042
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