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Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

BACKGROUND: Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson’s Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates Parkin activity leading to ubiquitination of multiple proteins, which in turn...

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Detalles Bibliográficos
Autores principales:	Martinez, Aitor, Lectez, Benoit, Ramirez, Juanma, Popp, Oliver, Sutherland, James D., Urbé, Sylvie, Dittmar, Gunnar, Clague, Michael J., Mayor, Ugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387213/ https://www.ncbi.nlm.nih.gov/pubmed/28399880 http://dx.doi.org/10.1186/s13024-017-0170-3

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