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Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia

BACKGROUND: Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to pro...

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Autores principales: Aleluia, Milena Magalhães, da Guarda, Caroline Conceição, Santiago, Rayra Pereira, Fonseca, Teresa Cristina Cardoso, Neves, Fábia Idalina, de Souza, Regiana Quinto, Farias, Larissa Alves, Pimenta, Felipe Araújo, Fiuza, Luciana Magalhães, Pitanga, Thassila Nogueira, Ferreira, Júnia Raquel Dutra, Adorno, Elisângela Vitória, Cerqueira, Bruno Antônio Veloso, Gonçalves, Marilda de Souza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387254/
https://www.ncbi.nlm.nih.gov/pubmed/28399852
http://dx.doi.org/10.1186/s12944-017-0454-1
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author Aleluia, Milena Magalhães
da Guarda, Caroline Conceição
Santiago, Rayra Pereira
Fonseca, Teresa Cristina Cardoso
Neves, Fábia Idalina
de Souza, Regiana Quinto
Farias, Larissa Alves
Pimenta, Felipe Araújo
Fiuza, Luciana Magalhães
Pitanga, Thassila Nogueira
Ferreira, Júnia Raquel Dutra
Adorno, Elisângela Vitória
Cerqueira, Bruno Antônio Veloso
Gonçalves, Marilda de Souza
author_facet Aleluia, Milena Magalhães
da Guarda, Caroline Conceição
Santiago, Rayra Pereira
Fonseca, Teresa Cristina Cardoso
Neves, Fábia Idalina
de Souza, Regiana Quinto
Farias, Larissa Alves
Pimenta, Felipe Araújo
Fiuza, Luciana Magalhães
Pitanga, Thassila Nogueira
Ferreira, Júnia Raquel Dutra
Adorno, Elisângela Vitória
Cerqueira, Bruno Antônio Veloso
Gonçalves, Marilda de Souza
author_sort Aleluia, Milena Magalhães
collection PubMed
description BACKGROUND: Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to provide knowledge about the SCA sub-phenotypes previously described and suggest a dyslipidemic sub-phenotype. METHODS: A cross-sectional study was conducted from 2013 to 2014, and 99 SCA patients in steady state were enrolled. We assessed correlations and associations with hematological and biochemical data and investigated the co-inheritance of -α(3.7Kb)-thalassemia (-α(3.7Kb)-thal). Correlation analyses were performed using Spearman and Pearson coefficient. The median of quantitative variables between two groups was compared using t-test and Mann-Whitney. P-values <0.05 were considered statistically significant. RESULTS: We found significant association of high lactate dehydrogenase levels with decreased red blood cell count and hematocrit as well as high levels of total and indirect bilirubin. SCA patients with low nitric oxide metabolites had high total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol and reduced very low-density cholesterol, triglycerides, direct bilirubin level and reticulocyte counts. In SCA patients with high-density lipoprotein cholesterol greater than 40 mg/dL, we observed increased red blood cell count, hemoglobin, hematocrit, and fetal hemoglobin and decreased nitric oxide metabolites levels. The presence of -α(3.7Kb)-thal was associated with high red blood cell count and low mean corpuscular volume, mean corpuscular hemoglobin, platelet count and total and indirect bilirubin levels. CONCLUSIONS: Our results provide additional information about the association between biomarkers and co-inheritance of -α(3.7Kb)-thal in SCA, and suggest the role of dyslipidemia and nitric oxide metabolites in the characterization of this sub-phenotype.
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spelling pubmed-53872542017-04-11 Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia Aleluia, Milena Magalhães da Guarda, Caroline Conceição Santiago, Rayra Pereira Fonseca, Teresa Cristina Cardoso Neves, Fábia Idalina de Souza, Regiana Quinto Farias, Larissa Alves Pimenta, Felipe Araújo Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Júnia Raquel Dutra Adorno, Elisângela Vitória Cerqueira, Bruno Antônio Veloso Gonçalves, Marilda de Souza Lipids Health Dis Research BACKGROUND: Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to provide knowledge about the SCA sub-phenotypes previously described and suggest a dyslipidemic sub-phenotype. METHODS: A cross-sectional study was conducted from 2013 to 2014, and 99 SCA patients in steady state were enrolled. We assessed correlations and associations with hematological and biochemical data and investigated the co-inheritance of -α(3.7Kb)-thalassemia (-α(3.7Kb)-thal). Correlation analyses were performed using Spearman and Pearson coefficient. The median of quantitative variables between two groups was compared using t-test and Mann-Whitney. P-values <0.05 were considered statistically significant. RESULTS: We found significant association of high lactate dehydrogenase levels with decreased red blood cell count and hematocrit as well as high levels of total and indirect bilirubin. SCA patients with low nitric oxide metabolites had high total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol and reduced very low-density cholesterol, triglycerides, direct bilirubin level and reticulocyte counts. In SCA patients with high-density lipoprotein cholesterol greater than 40 mg/dL, we observed increased red blood cell count, hemoglobin, hematocrit, and fetal hemoglobin and decreased nitric oxide metabolites levels. The presence of -α(3.7Kb)-thal was associated with high red blood cell count and low mean corpuscular volume, mean corpuscular hemoglobin, platelet count and total and indirect bilirubin levels. CONCLUSIONS: Our results provide additional information about the association between biomarkers and co-inheritance of -α(3.7Kb)-thal in SCA, and suggest the role of dyslipidemia and nitric oxide metabolites in the characterization of this sub-phenotype. BioMed Central 2017-04-11 /pmc/articles/PMC5387254/ /pubmed/28399852 http://dx.doi.org/10.1186/s12944-017-0454-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Aleluia, Milena Magalhães
da Guarda, Caroline Conceição
Santiago, Rayra Pereira
Fonseca, Teresa Cristina Cardoso
Neves, Fábia Idalina
de Souza, Regiana Quinto
Farias, Larissa Alves
Pimenta, Felipe Araújo
Fiuza, Luciana Magalhães
Pitanga, Thassila Nogueira
Ferreira, Júnia Raquel Dutra
Adorno, Elisângela Vitória
Cerqueira, Bruno Antônio Veloso
Gonçalves, Marilda de Souza
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
title Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
title_full Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
title_fullStr Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
title_full_unstemmed Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
title_short Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
title_sort association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387254/
https://www.ncbi.nlm.nih.gov/pubmed/28399852
http://dx.doi.org/10.1186/s12944-017-0454-1
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