Absence of physiological Ca(2+) transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

BACKGROUND: Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitochondrial reactive oxygen species (ROS) production...

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Detalles Bibliográficos
Autores principales: Karam, Chehade, Yi, Jianxun, Xiao, Yajuan, Dhakal, Kamal, Zhang, Lin, Li, Xuejun, Manno, Carlo, Xu, Jiejia, Li, Kaitao, Cheng, Heping, Ma, Jianjie, Zhou, Jingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387329/
https://www.ncbi.nlm.nih.gov/pubmed/28395670
http://dx.doi.org/10.1186/s13395-017-0123-0

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