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Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors

The modulation of PPIs by low molecular weight chemical compounds, particularly by orally bioavailable molecules, would be very valuable in numerous disease indications. However, it is known that PPI inhibitors (iPPIs) tend to have properties that are linked to poor Absorption, Distribution, Metabol...

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Detalles Bibliográficos
Autores principales:	Lagorce, David, Douguet, Dominique, Miteva, Maria A., Villoutreix, Bruno O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387685/ https://www.ncbi.nlm.nih.gov/pubmed/28397808 http://dx.doi.org/10.1038/srep46277

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