Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity

Wnt/β-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human cancers. Previously, we uncovered NC043 as a small-molecule inhibitor of Wnt/β-catenin signaling. Here, we identified CARF as the cellular target of NC043. We found that NC0...

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Detalles Bibliográficos
Autores principales: He, Xiaoli, Zhang, Wenjuan, Yan, Chen, Nie, Fen, Li, Chen, Liu, Xiaofen, Fei, Cong, Li, Shengdi, Song, Xiaomin, Jia, Yingying, Zeng, Rong, Wu, Dianqing, Pan, Weijun, Hao, Xiaojiang, Li, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387711/
https://www.ncbi.nlm.nih.gov/pubmed/28417011
http://dx.doi.org/10.1038/celldisc.2017.3

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