Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy

Signal transducer and activator of transcription 3 (STAT3) is a well-known antitumor target. Exogenous ROS insult can lead to selective cytotoxicity against cancer cells. A combination of STAT3 inhibition and “oxidation therapy” may be a new strategy to address the multidrug-resistance issue due to...

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Detalles Bibliográficos
Autores principales: Zhang, Wenda, Guo, Jianpeng, Li, Shanshan, Ma, Ting, Xu, Dingqiao, Han, Chao, Liu, Feiyan, Yu, Wenying, Kong, Lingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387716/
https://www.ncbi.nlm.nih.gov/pubmed/28397855
http://dx.doi.org/10.1038/srep46352

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