Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation

Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impa...

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Detalles Bibliográficos
Autores principales: Liu, Ruiquan, Wang, Lei, Li, Qibo, Liao, Min, Yang, Zhikun, Huang, Yun, Lv, Cong, Zheng, Bing, Zhong, Jiangchun, Bian, Qinghua, Wang, Min, Liu, Shangzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387731/
https://www.ncbi.nlm.nih.gov/pubmed/28397807
http://dx.doi.org/10.1038/srep45927
Descripción
Sumario:Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impact on the antimicrobial activities. The synthesis of Chrysogeside B and analogues designed to allow identification of the features of this glycolipid required for recognition by tested bacteria and Hela cells is described.

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