Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation

Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impa...

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Autores principales: Liu, Ruiquan, Wang, Lei, Li, Qibo, Liao, Min, Yang, Zhikun, Huang, Yun, Lv, Cong, Zheng, Bing, Zhong, Jiangchun, Bian, Qinghua, Wang, Min, Liu, Shangzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387731/
https://www.ncbi.nlm.nih.gov/pubmed/28397807
http://dx.doi.org/10.1038/srep45927
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author Liu, Ruiquan
Wang, Lei
Li, Qibo
Liao, Min
Yang, Zhikun
Huang, Yun
Lv, Cong
Zheng, Bing
Zhong, Jiangchun
Bian, Qinghua
Wang, Min
Liu, Shangzhong
author_facet Liu, Ruiquan
Wang, Lei
Li, Qibo
Liao, Min
Yang, Zhikun
Huang, Yun
Lv, Cong
Zheng, Bing
Zhong, Jiangchun
Bian, Qinghua
Wang, Min
Liu, Shangzhong
author_sort Liu, Ruiquan
collection PubMed
description Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impact on the antimicrobial activities. The synthesis of Chrysogeside B and analogues designed to allow identification of the features of this glycolipid required for recognition by tested bacteria and Hela cells is described.
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spelling pubmed-53877312017-04-14 Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation Liu, Ruiquan Wang, Lei Li, Qibo Liao, Min Yang, Zhikun Huang, Yun Lv, Cong Zheng, Bing Zhong, Jiangchun Bian, Qinghua Wang, Min Liu, Shangzhong Sci Rep Article Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impact on the antimicrobial activities. The synthesis of Chrysogeside B and analogues designed to allow identification of the features of this glycolipid required for recognition by tested bacteria and Hela cells is described. Nature Publishing Group 2017-04-11 /pmc/articles/PMC5387731/ /pubmed/28397807 http://dx.doi.org/10.1038/srep45927 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liu, Ruiquan
Wang, Lei
Li, Qibo
Liao, Min
Yang, Zhikun
Huang, Yun
Lv, Cong
Zheng, Bing
Zhong, Jiangchun
Bian, Qinghua
Wang, Min
Liu, Shangzhong
Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation
title Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation
title_full Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation
title_fullStr Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation
title_full_unstemmed Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation
title_short Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation
title_sort synthesis of chrysogeside b from halotolerant fungus penicillium and its antimicrobial activities evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387731/
https://www.ncbi.nlm.nih.gov/pubmed/28397807
http://dx.doi.org/10.1038/srep45927
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