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A promising biodegradable magnesium alloy suitable for clinical vascular stent application

We report a Mg alloy Mg-2.2Nd-0.1Zn-0.4Zr (wt.%, denoted as JDBM-2) showing great potential in clinical vascular stent application by integrating the advantages of traditional medical stainless steel and polymer. This alloy exhibits high yield strength and elongation of 276 ± 6 MPa and 34.3 ± 3.4% r...

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Autores principales: Mao, Lin, shen, Li, Chen, Jiahui, Zhang, Xiaobo, Kwak, Minsuk, Wu, Yu, Fan, Rong, Zhang, Lei, Pei, Jia, Yuan, Guangyin, Song, Chengli, Ge, Junbo, Ding, Wenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387745/
https://www.ncbi.nlm.nih.gov/pubmed/28397881
http://dx.doi.org/10.1038/srep46343
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author Mao, Lin
shen, Li
Chen, Jiahui
Zhang, Xiaobo
Kwak, Minsuk
Wu, Yu
Fan, Rong
Zhang, Lei
Pei, Jia
Yuan, Guangyin
Song, Chengli
Ge, Junbo
Ding, Wenjiang
author_facet Mao, Lin
shen, Li
Chen, Jiahui
Zhang, Xiaobo
Kwak, Minsuk
Wu, Yu
Fan, Rong
Zhang, Lei
Pei, Jia
Yuan, Guangyin
Song, Chengli
Ge, Junbo
Ding, Wenjiang
author_sort Mao, Lin
collection PubMed
description We report a Mg alloy Mg-2.2Nd-0.1Zn-0.4Zr (wt.%, denoted as JDBM-2) showing great potential in clinical vascular stent application by integrating the advantages of traditional medical stainless steel and polymer. This alloy exhibits high yield strength and elongation of 276 ± 6 MPa and 34.3 ± 3.4% respectively. The JDBM-2 with a stable degradation surface results in a highly homogeneous degradation mechanism and long-term structural and mechanical durability. In vitro cytotoxicity test of the Mg extract via human vascular endothelial cells (HUVECs) indicates that the corrosion products are well tolerated by the tested cells and potentially negligible toxic effect on arterial vessel walls. This alloy also exhibits compromised foreign body response (FBR) determined by human peripheral blood derived macrophage adhesion, foreign body giant cell (FBGC) formation and inflammatory cytokine and chemokine secretion. Finally, vascular stents manufactured from the JDBM-2 were implanted into rabbits for long-term evaluation. The results confirm excellent tissue compatibility and up to 6-month structural and mechanical integrity of the stent in vivo. Thus, the JDBM-2 stent with up to 6-month structural and mechanical integrity and excellent tissue compatibility represents a major breakthrough in this field and a promising alternative to traditional medical stainless steel and polymer for the clinical application.
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spelling pubmed-53877452017-04-14 A promising biodegradable magnesium alloy suitable for clinical vascular stent application Mao, Lin shen, Li Chen, Jiahui Zhang, Xiaobo Kwak, Minsuk Wu, Yu Fan, Rong Zhang, Lei Pei, Jia Yuan, Guangyin Song, Chengli Ge, Junbo Ding, Wenjiang Sci Rep Article We report a Mg alloy Mg-2.2Nd-0.1Zn-0.4Zr (wt.%, denoted as JDBM-2) showing great potential in clinical vascular stent application by integrating the advantages of traditional medical stainless steel and polymer. This alloy exhibits high yield strength and elongation of 276 ± 6 MPa and 34.3 ± 3.4% respectively. The JDBM-2 with a stable degradation surface results in a highly homogeneous degradation mechanism and long-term structural and mechanical durability. In vitro cytotoxicity test of the Mg extract via human vascular endothelial cells (HUVECs) indicates that the corrosion products are well tolerated by the tested cells and potentially negligible toxic effect on arterial vessel walls. This alloy also exhibits compromised foreign body response (FBR) determined by human peripheral blood derived macrophage adhesion, foreign body giant cell (FBGC) formation and inflammatory cytokine and chemokine secretion. Finally, vascular stents manufactured from the JDBM-2 were implanted into rabbits for long-term evaluation. The results confirm excellent tissue compatibility and up to 6-month structural and mechanical integrity of the stent in vivo. Thus, the JDBM-2 stent with up to 6-month structural and mechanical integrity and excellent tissue compatibility represents a major breakthrough in this field and a promising alternative to traditional medical stainless steel and polymer for the clinical application. Nature Publishing Group 2017-04-11 /pmc/articles/PMC5387745/ /pubmed/28397881 http://dx.doi.org/10.1038/srep46343 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Mao, Lin
shen, Li
Chen, Jiahui
Zhang, Xiaobo
Kwak, Minsuk
Wu, Yu
Fan, Rong
Zhang, Lei
Pei, Jia
Yuan, Guangyin
Song, Chengli
Ge, Junbo
Ding, Wenjiang
A promising biodegradable magnesium alloy suitable for clinical vascular stent application
title A promising biodegradable magnesium alloy suitable for clinical vascular stent application
title_full A promising biodegradable magnesium alloy suitable for clinical vascular stent application
title_fullStr A promising biodegradable magnesium alloy suitable for clinical vascular stent application
title_full_unstemmed A promising biodegradable magnesium alloy suitable for clinical vascular stent application
title_short A promising biodegradable magnesium alloy suitable for clinical vascular stent application
title_sort promising biodegradable magnesium alloy suitable for clinical vascular stent application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387745/
https://www.ncbi.nlm.nih.gov/pubmed/28397881
http://dx.doi.org/10.1038/srep46343
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